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Title   비호지킨 림프종에 대한 COP - BLAM V ( Cyolophosphamide / Vincristine / Prednisone / Bleomycin / Adriamycin / Procarbazine ) 복합화학요법의 치료효과 ( COP - BLAM V ( Cyolophosphamide / Vincristine / Prednisone / Bleomycin / Adriamycin / Procarbazine ) Combination Chemotherapy
Publicationinfo   1992 Jan; 024(02): 268-277.
Key_word   COP-BLAM V, Non-Hodgikins lymphoma
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Abstract   Between Ap. 1989 and Jul. 1991, 42 patients with the intermediate and high grade Non-Hodg- kins lymphoma were treated with COP-BLAM V(cyclophosphamide, bleomycin, prednisone, vincristine, adriamycin, procarbazine) infusional chemotherapy. The median age was 53yrs(range 19~77) and male to female ratio was 30: 1 1. No patients received any previous cytotoxic chemotherapy, and the common histologic typeswere diffuse histiocytic type(74k) and immunoblastic type(14%). The proportion of patients with B'symptoms, or bulky mass, or LDH>400 at diagnosis was 31%, 17%, 19%, respectively. The rate of complete remission was 74%(31/42) and overal response rate was 95/(40/42). The median-disease free interval was 14 months(1.5'-23). The range of survival time was from 2' to 24' months. 2year survival rate was 78.5/ but the median survival time was not reached right now(the median follow up time: 12.5months) The leukopenia(26%) and anemia(14%) were the hematologic toxicities. Non-hematologic side effects were moderate and severe G-I symptoms-nausea, vomiting(31%), alopecia(69%), stomati- tis(12%) and pulmonary toxity(14%), two treatment related deaths were associated with sepsis and acute respiratory distress syndrome(ARDS). Based on high complete response rate and tolerable toxicitiy, COP-BLAM V seems to be an effective treatment regimen for the intermediate and high grade Non-Hodgkins lymphoma. To confirm the efficacy further, long-term follow up and the phase III randomised comparision with other regimens will be needed.
저 자   박영이(Young Iee Park),이기형(Kee Hyung Lee),정경혜(Keong Hae Jung),윤성수(Sung Soo Yoon),임영혁(Yeong Juck Im),장정순(Jung Soon Jang),이재용(Jae Yong Lee),허대석(Dae Suck Heo),방영주(Yung Jue Bang),박선양(Seonyang Park),김병국(Beyoung Kook Kim),김노겸(Noe Kyeong Kim),강윤구(Yoon Koo Kang)